Angiotensin II acetate salt

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Quality level: 200

Biological source: synthetic

Test: ≥93% (HPLC)

Form: dust

Application(s)

cell culture | mammal: suitable:

Impurities: 1.2-10.4% acetate

Storage temperature: −20 ° C

InChI

1S / C50H71N13O12 / c1-5-28 (4) 41 (47 (72) 59-36 (23-31-25-54-26-56-31) 48 (73) 63-20-10-14-38 ( 63) 45 (70) 60-37 (49 (74) 75) 22-29-11-7-6-8-12-29) 62-44 (69) 35 (21-30-15-17-32 ( 64) 18-16-30) 58-46 (71) 40 (27 (2) 3) 61-43 (68) 34 (13-9-19-55-50 (52) 53) 57-42 (67) 33 (51) 24-39 (65) 66 / h6-8.11-12.15-18.25-28.33-38.40-41.64H, 5.9-10.13-14.19- 24.51H2.1-4H3, (H, 54.56) (H, 57.67) (H, 58.71) (H, 59.72) (H, 60.70) (H, 61.68) (H, 62.69) (H, 65.66) (H, 74.75) (H4.52.53.55) / t28-, 33-, 34-, 35-, 36-, 37-, 38 -, 40-, 41? / M0 / s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Genetic information: human … AGT (183)

Amino acid sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

Request

  • Human angiotensin II (any) has been used to study its effect on interleukin-1β-mediated islet inflammation and β-cell dysfunction.
  • It has been used to determine whether angII activates specific isoforms of calcineurin-dependent NFAT (nuclear factor of activated T cells) in cardiomyocytes.
  • It has been used to study the actions of systemic infusions of angII on glomerular patency in vivo.
  • It has been used to test the effects of age on plasma triglyceride production and its association with insulin resistance in normal rats.

Biochemical / Physiological Actions

Angiotensin II (angII) is an octapeptide hormone that affects the activities of the heart, kidneys, vasculature, and brain. Angiotensinogen is the blood is produced from angiotensinogen through the renin and angiotensin-converting enzyme (ACE). It works by binding to specific receptors present on cell membranes. AngII is a component of the renin-angiotensin system. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of proto-oncogene expression, modulation of myocardial hypertrophy, renal failure, and fibrosis.

Features and Benefits

The purity of our human angiotensin II, Ang II, is verified to ensure its experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Antibody adsorbent

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

Analysis note

Peptide content not less than 75%.

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